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N-(4-(((2,6-DIMETHYLPHENOXY)ACETYL)AMINO)-3-HYDROXY-5-PHENYL-1-(PHENYLMETHYL)PENTYL)TETRAHYDRO-ALPHA-(1-METHYLETHYL)-2-OXO-1(2H)-PYDRIMIDINEACETAMIDE
Descriptors Found:
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DeCS
Descriptor
English
:
Lopinavir
Descriptor
Spanish
:
Lopinavir
Descriptor
Portuguese
:
Lopinavir
Synonyms
English
:
A-157378.0
ABT 378
ABT-378
N-(4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide
A 157378.0
A157378.0
ABT378
Tree Number:
D03.383.742.698.553
Definition
English
:
An
HIV protease
inhibitor used in a fixed-dose combination with
RITONAVIR
. It is also an inhibitor of
CYTOCHROME P-450 CYP3A.
Pharmacological Action:
Cytochrome P-450 CYP3A Inhibitors
HIV Protease Inhibitors
History Note
English
:
2012
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
54552
Unique Identifier:
D061466
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS