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FOLLISTATIN
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DeCS
Descriptor
English
:
Follistatin
Descriptor
Spanish
:
Folistatina
Descriptor
Portuguese
:
Folistatina
Synonyms
English
:
Activin Binding Protein
Activin-Binding Protein
Tree Number:
D12.776.157.247
Definition
English
:
A broadly distributed protein that binds directly to
ACTIVINS
. It functions as an activin antagonist, inhibits
FOLLICLE STIMULATING HORMONE
secretion, regulates
CELL DIFFERENTIATION
, and plays an important role in embryogenesis.
Follistatin
is a single glycosylated polypeptide chain of approximately 37-kDa and is not a member of the inhibin
family
(
INHIBINS
).
Follistatin
also binds and neutralizes many members of the
TRANSFORMING GROWTH FACTOR BETA
family.
History Note
English
:
2003; use FOLLISTATIN (NM) 1988-2002
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
37390
Unique Identifier:
D038681
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS