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DeCS
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Descriptor English:
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Droxidopa
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Descriptor Spanish:
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Droxidopa
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Descriptor Portuguese:
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Droxidopa
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Synonyms English:
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3,4-threo-DOPS
DL-threo-3,4-Dihydroxyphenylserine
Droxidopa, (DL-Tyr)-Isomer
erythro-3,4-Dihydroxyphenylserine
threo-DOPS
3,4 Dihydroxyphenylserine
3,4 threo DOPS
DL threo 3,4 Dihydroxyphenylserine
erythro 3,4 Dihydroxyphenylserine
threo DOPS
3,4-Dihydroxyphenylserine
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Tree Number:
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D02.092.211.215.311.560.220
D02.092.311.830.220
D12.125.154.800.875
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Definition English:
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A precursor of noradrenaline that is used in the treatment of parkinsonism. The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995) |
Pharmacological Action:
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Antiparkinson Agents
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History Note English:
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97; was 3,4-DIHYDROXYPHENYLSERINE 1975-96 (see under SERINE 1975-90); DOPS was see DIHYDROXYPHENYLSERINE 1975-96
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Allowable Qualifiers English:
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Record Number:
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4140
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Unique Identifier:
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D015103
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Occurrence in VHL:
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Similar:
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DeCS CID-10 LILACS
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