Search on: TRETINOIN 
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Descriptor English:   Tretinoin 
Descriptor Spanish:   Tretinoina 
Descriptor Portuguese:   Tretinoína 
Synonyms English:   Retin-A
Tretinoin Potassium Salt
Tretinoin Sodium Salt
Tretinoin Zinc Salt
Vesanoid
all-trans-Retinoic Acid
beta-all-trans-Retinoic Acid
trans-Retinoic Acid
Acid, Retinoic
Acid, Vitamin A
Acid, all-trans-Retinoic
Acid, beta-all-trans-Retinoic
Acid, trans-Retinoic
Potassium Salt, Tretinoin
Retin A
Salt, Tretinoin Potassium
Salt, Tretinoin Sodium
Salt, Tretinoin Zinc
Sodium Salt, Tretinoin
Zinc Salt, Tretinoin
all trans Retinoic Acid
beta all trans Retinoic Acid
trans Retinoic Acid
Retinoic Acid
Vitamin A Acid  
Tree Number:   D02.455.326.271.665.202.495.818.500
D02.455.426.392.368.367.379.249.700.860.500
D02.455.849.131.495.818.800
D23.767.261.700.780
Definition English:   An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE). 
Pharmacological Action:   Antineoplastic Agents
Keratolytic Agents
 
See Related English:   Receptors, Retinoic Acid
 
History Note English:   80(75); was see under VITAMIN A 1975-79 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   14606 
Unique Identifier:   D014212 

Occurrence in VHL: 		 

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