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DeCS
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Descriptor English:
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Presenilin-1
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Descriptor Spanish:
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Presenilina-1
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Descriptor Portuguese:
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Presenilina-1
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Synonyms English:
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Presenilin 1
S182 Protein
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Tree Number:
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D12.776.543.696.500
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Definition English:
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Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans. |
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History Note English:
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2007
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Allowable Qualifiers English:
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Record Number:
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52334
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Unique Identifier:
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D053764
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Occurrence in VHL:
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Similar:
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DeCS CID-10 LILACS
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