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DeCS
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Descriptor English:
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Ivermectin
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Descriptor Spanish:
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Ivermectina
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Descriptor Portuguese:
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Ivermectina
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Synonyms English:
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Eqvalan
Ivomec
MK-933
Mectizan
Stromectol
MK 933
MK933
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Tree Number:
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D02.540.576.500.997
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Definition English:
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A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form. |
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Pharmacological Action:
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Antiparasitic Agents
Insecticides
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History Note English:
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1987; for MECTIZAN use IVERMECTIN (NM) 1987-1999
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Allowable Qualifiers English:
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Record Number:
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19221
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Unique Identifier:
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D007559
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Occurrence in VHL:
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Similar:
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DeCS CID-10 LILACS
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