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AMANITINS
Descriptors Found:
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DeCS
Descriptor
English
:
Amanitins
Descriptor
Spanish
:
Amanitinas
Descriptor
Portuguese
:
Amanitinas
Tree Number:
D04.345.566.050
D12.644.456.050
D12.644.641.050
D23.946.587.175
Definition
English
:
Cyclic
peptides
extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These
peptides
are important in the study of transcription.
Alpha-amanitin
is the main toxin from the species Amanitia phalloides, poisonous if ingested by
humans
or
animals.
Indexing Annotation
English
:
/antag permitted but consider also
ANTITOXINS
Pharmacological Action:
Enzyme Inhibitors
Nucleic Acid Synthesis Inhibitors
Poisons
History Note
English
:
75
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
546
Unique Identifier:
D000546
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS